Good morning.
It’s the eve of tariff-induced “Liberation Day,” and the S&P 500 and the Nasdaq just ended their worst quarters since 2022. So everyone is a little stressed out. But BlackRock CEO Larry Fink has a message to America: This too shall pass.
In his annual letter to investors, published Monday, Fink wrote that while economic anxiety appears to be at an all-time high, “we have lived through moments like this before. And somehow, in the long run, we figure things out.” And, in fact, across the wide-ranging 27-page letter, Fink laid out a pretty clear roadmap of how to “figure things out.” His ideas include: launching “baby bonds” for every American, embracing nuclear power, and forgoing the traditional 60/40 stocks-and-bonds investing portfolio for a 50/30/20 split that folds in private assets like real estate and infrastructure, the latter of which he says will become a $68 trillion investment market by 2040. It’s all in an effort to “democratize finance” and increase access to private markets. Which would just so happen to be pretty good for BlackRock’s bottom line.
Markets Eat Their Carats As Gold Touches New Record High

In times of economic uncertainty, some investors follow a literal golden rule: Buy it.
Adherence to that time-honoured tradition was on display Monday, as gold prices topped $3,100 per ounce, the latest in a string of record highs that have pushed the precious metal — up 18% so far this year — to its biggest quarterly gain in 39 years. Will it continue to climb? Most analysts say yes, but one has a big caveat.
A Bullion Questions
Gold is viewed as a safe-haven asset for lots of reasons: Its value has generally increased over time, it can be but is not always a hedge against inflation, and its inverse relationship with the dollar can counterbalance currency fluctuations. The general idea is that gold’s relative stability can help preserve wealth when market volatility and geopolitical risks are on the rise.
As you know — unless you’ve just returned from a Tom Hanks Cast Away experience — those risks have risen dramatically in recent months. Amid an increasing probability of additional US tariffs, Goldman Sachs warned clients late Sunday that it now sees a 35% chance of a US recession in the next 12 months. JPMorgan’s chief global economist, Bruce Kasman, was more pessimistic earlier this month, putting the chance at 40%, while former Treasury Secretary and Harvard economist Larry Summers called it a coin flip. Which brings us back to gold: With no apparent end to the uncertainty in sight, will the precious metal still be worth its weight in itself? Forecasts say yes, but there’s a bold, contrarian view:
- Last week, Bank of America hiked its target price for gold to an average $3,350 per ounce in 2026, adding that it could go up to $3,500 if demand grows by 10% — Goldman also lifted its year-end price forecast to $3,300 per ounce. BofA’s analysts said central banks, where gold makes up roughly 10% of reserves, could increase that share to 30% or higher.
- On the other hand, Morningstar analysts have argued in recent weeks that gold may fall almost 40% to $1,820 in the next five years. Among their reasons: High prices have compelled miners to expand production (gold inventories have increased 9% in the past five years, according to the World Gold Council); a decrease in inflation could slow gold’s rise; and so-called “demand destruction” (as much as 15% of gold is used by industries, which could substitute cheaper materials to save costs, driving down demand and prices in the process).
Don’t Central Bank on It: It’s uncertain whether one key driver that BofA analysts are counting on will materialize. While a handful of central banks, including in Uzbekistan, China and Kazakhstan, have bought bullion to start the year, activity from reserve institutions is down from last year. Meanwhile, 71% of central banks surveyed by the World Gold Council in June last year said they didn’t plan on increasing their stockpiles in the following 12 months.
Google-Backed AI Drug-Developer Isomorphic Labs Secures $600 Million
Turns out AI can be used for more than Ghibli-ifying selfies. AI drug developer Isomorphic Labs raised $600 million in its first external funding round as hype builds around AI-powered biotech.
Investing firm Thrive Capital led the round, while Alphabet and its venture arm GV also added funds. Isomorphic was spun off from Google’s AI unit DeepMind four years ago.
Though Isomorphic is burning through millions on research and development now, investors have high hopes for AI’s potential to spur the formulation of new medical treatments.
Searching for New Scrips
Isomorphic CEO Sir Demis Hassabis said Isomorphic’s latest funding round is “a significant step forward towards our mission of one day solving all disease with the help of AI.” Billions are being thrown around to get Isomorphic, and its competitors, closer to achieving that lofty goal:
- Isomorphic secured partnerships worth almost $3 billion with drug developers Eli Lilly and Novartis last year.
- Beyond Isomorphic, Valo Health signed a nearly $5 billion deal with Novo Nordisk to develop obesity drugs using AI, and Recursion Pharmaceuticals made a $1.5 billion agreement with Bayer for AI-driven cancer drug discovery.
Isomorphic made a breakthrough last year, when it unveiled AlphaFold 3, an AI model that can predict the structures of DNA, RNA, and disease markers known as ligands. DeepMind and Isomorphic CEO Hassabis co-won the Nobel Prize in chemistry for AlphaFold, which can be used to run drug-development simulations.
AI models like AlphaFold could one day let researchers discover new drugs at their desks, mostly with their computers, instead of in a lab using beakers of chemicals. That’s expected to speed up drug development, cut costs, and potentially create more effective treatment options.
More Than Meets the AI: AI-developed drugs haven’t hit pharmacy shelves yet, but a handful have made it to the testing stage — where they’ve yielded promising results. ScienceDirect found in a study that AI-discovered molecules (the building blocks of drugs) have substantially higher success rates (up to 90%) during early trials than the average. So while much of the hype around AI has focused on improved search engines and generating quirky pics and videos, it has other promising, if slightly less flashy, applications.
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Rocket Mortgage Acquires Mr. Cooper to Create an Industry Giant
How’s this for a rocket-like trajectory?
As the ink dries on its agreement earlier this month to buy RedFin for $1.75 billion, lender Rocket Mortgage announced on Monday the next item in its M&A shopping spree: a $9.4 billion takeover of mortgage servicing giant Mr. Cooper.
Cooper D’etat
Rocket’s dual acquisitions give the company a stake in three major sections of the home-buying market. First: browse and shop for a new home on RedFin, the digital platform home to more than 1 million for-sale and for-rent listings. Second: Obtain a mortgage loan via Rocket, which ended 2024 as the third-largest originator of mortgages in the US behind PennyMac and United Wholesale Mortgages. And third: Service that loan through Mr. Cooper.
Combined, Rocket and Mr. Cooper will service a $2.1 trillion loan book across some 10 million clients. They’ll also create a business that should, theoretically, naturally balance itself out no matter the ebbs and flows of interest rates:
- Periods of high interest rates tend to be relatively tough for originators like Rocket, which keeps few loans on its books, as fewer customers buy homes or refinance their existing mortgages. Conversely, high rates tend to be good times for servicers like Mr. Cooper, as existing borrowers tend to keep their current mortgage rather than refinance.
- Low rates, meanwhile, mark good times for originators like Rocket, sparking a surge in new and refinanced mortgages, which in turn disrupts the extended payments that servicers enjoy in the high-rate environment. These days, mortgage rates remain pretty high: While down from the 8% seen in late 2023, the average 30-year fixed mortgage rate was still 6.79% on Monday, according to Zillow.
Consolidation Prize: As home buying slows to a crawl — existing home sales last year fell to their lowest level since 1995 — the mortgage industry has shrunk and consolidated. Only 145 lenders originated at least $2 billion in mortgages last year, compared with 196 in 2022, Garth Graham, a senior partner at mortgage advisory firm Stratmor Group, told The Wall Street Journal. Whether that’s been good or bad for home buyers is a bit of an open question, but Rocket — likely to face at least some antitrust scrutiny as it completes both the RedFin and Mr. Cooper acquisitions this year — swears its bigger business will be good for clients, saving potentially as much as $20,000 in fees in the process of buying a typical $430,000 home.
Extra Upside
- News Flash: Shares of right-wing cable news company Newsmax soar more than 700% in its New York Stock Exchange debut.
- Brake Check: Tesla shares finish the first quarter down 36%, marking their worst quarter since 2022 and third-steepest quarterly drop ever.
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